2003 MAY 12 - (NewsRx.com & NewsRx.net) -- p15 methylation was an early event in the evolution of some AML patients.
"Seventeen patients with therapy-related myelodysplastic syndrome/acute myeloid leukemia (t-MDS/AML) were examined for aberrant p15 gene methylation by methylation-specific polymerase chain reaction," researchers in the Peoples Republic of China report.
"Ten patients (58%) showed p15 methylation, which was significantly related to monosomy/deletion of chromosome 7q, but not to antecedent chemotherapy, blast count, leukemic evolution or survival.
"In three of six patients with marrow samples obtained prior to the diagnosis of t-MDS/AML, …
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